The 2024 NFL season continues with a big slate of games on the NFL Week 2 schedule, with some contenders facing some very big early-season tests.
Among them: The Buffalo Bills and Miami Dolphins face off on Thursday Night Football to open the week. On Sunday, the Las Vegas Raiders meet the Baltimore Ravens, the Tampa Bay Buccaneers play the Detroit Lions, the Cleveland Browns match up against the Jacksonville Jaguars, the Cincinnati Bengals face the Kansas City Chiefs, the Chicago Bears take on the Houston Texans and the Atlanta Falcons and Philadelphia Eagles conclude the week on Monday Night Football.
Which teams will pass their NFL Week 2 tests?
Check out our NFL Week 2 picks and NFL Week 2 predictions for the 16 NFL Week 2 games.
All times MST. Click on each game for more picks and predictions for that matchup.
NFL Week 2 picks: Bills vs Dolphins | Raiders vs Ravens | Chargers vs Panthers | Saints vs Cowboys | Buccaneers vs Lions | Colts vs Packers | Browns vs Jaguars | 49ers vs Vikings | Seahawks vs Patriots | Jets vs Titans | Giants vs Commanders | Rams vs Cardinals | Steelers vs Broncos | Bengals vs Chiefs | Bears vs Texans | Falcons vs Eagles | The Arizona Republic's predictions
Thursday Night Football prediction, Sept. 12
Buffalo Bills at Miami Dolphins, 5:15 p.m., Prime Video (stream on Amazon)
Judging by the point spread in this game, we could be in for a treat to start off the week. The winner of this game gets an early edge in the AFC East, which could be very interesting. We'll take the home team in a nail-biter.
Prediction: Dolphins 27, Bills 24
NFL Week 2 schedule:Television channels, how to watch, stream games
Sunday early NFL football game predictions, Sept. 15
Las Vegas Raiders at Baltimore Ravens, 10 a.m., CBS (stream with free trial from FUBO)
The Ravens are the biggest favorite of the week and for good reason. Lamar Jackson and company should roll against Las Vegas.
Prediction: Ravens 31, Raiders 13
Los Angeles Chargers at Carolina Panthers, 10 a.m., CBS (stream with free trial from FUBO)
The Chargers seemed to put things together late in Week 1. That's bad news for a Panthers team that allowed 47 points in its first game.
Prediction: Chargers 27, Panthers 10
New Orleans Saints at Dallas Cowboys, 10 a.m., FOX (stream with free trial from FUBO)
Both of these teams impressed in Week 1, but the Cowboys really impressed on the road against a tougher opponent.
Prediction: Cowboys 28, Saints 20
Tampa Bay Buccaneers at Detroit Lions, 10 a.m., FOX (stream with free trial from FUBO)
These teams faced off in the NFL postseason last year and we wouldn't be shocked if they ended up playing again in this postseason. Get your popcorn ready for this one.
Prediction: Lions 24, Buccaneers 23
Indianapolis Colts at Green Bay Packers, 10 a.m., FOX (stream with free trial from FUBO)
We probably would have picked the Packers in this game a week ago, but Jordan Love's injury looms large for Green Bay.
Prediction: Colts 24, Packers 16
Cleveland Browns at Jacksonville Jaguars, 10 a.m., CBS (stream with free trial from FUBO)
Both of these teams did not impress in Week 1, but we're higher on Trevor Lawrence and the Jaguars turning it around at home in Week 2.
Prediction: Jaguars 20, Browns 17
San Francisco 49ers at Minnesota Vikings, 10 a.m., CBS (stream with free trial from FUBO)
The Vikings impressed in Week 1, but it was against the New York Giants. Beating the 49ers will be much more difficult.
Prediction: 49ers 27, Vikings 17
Seattle Seahawks at New England Patriots, 10 a.m., FOX (stream with free trial from FUBO)
Geno Smith is the forgotten QB in the NFC West. He shouldn't be. If he's on, Seattle can cause problems.
Prediction: Seahawks 21, Patriots 17
New York Jets at Tennessee Titans, 10 a.m., CBS (stream with free trial from FUBO)
The Titans won't win many games if Will Levis continues to turn the ball over at a high rate.
Prediction: Jets 24, Titans 16
New York Giants at Washington Commanders, 10 a.m., FOX (stream with free trial from FUBO)
Both of these teams struggled in Week 1 losses, but at least the Commanders found the end zone.
Prediction: Commanders 27, Giants 13
NFL Week 2 odds:Point spreads, moneylines, over/unders for betting on games
Sunday late NFL football game predictions, Sept. 15
Los Angeles Rams at Arizona Cardinals, 1:05 p.m., FOX (stream with free trial from FUBO)
The line is close for this game, but we just don't have much faith in the Cardinals' defense. Maybe it will step up at home.
Prediction: Rams 31, Cardinals 27
Pittsburgh Steelers at Denver Broncos, 1:25 p.m., CBS (stream with free trial from FUBO)
Could Justin Fields permanently wrestle the starting QB job away from Russell Wilson in Pittsburgh? QBs will be the center of attention in this game.
Prediction: Broncos 20, Steelers 17
Cincinnati Bengals at Kansas City Chiefs, 1:25 p.m., CBS (stream with free trial from FUBO)
Cincinnati should be fired up for this game, especially after its abysmal Week 1 performance. But, it's hard to win in Kansas City.
Prediction: Chiefs 24, Bengals 20
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Sunday Night Football prediction, Sept. 15
Chicago Bears at Houston Texans, 5:20 p.m., NBC (stream with Peaco*ck)
If Week 1 was any indication, Caleb Williams and the Bears could be a headache for teams this season. This could be a very intriguing game in Houston.
Prediction: Texans 27, Bears 23
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Monday Night Football prediction, Sept. 16
Atlanta Falcons at Philadelphia Eagles, 5:15 p.m., ESPN (stream with free trial from FUBO)
We expected much more from the Falcons' offense in Week 1. Can it soar with the Eagles' offense in Week 2? We have our doubts.
Prediction: Eagles 30, Falcons 20
NOTE:NFL games can be streamed locally on FUBO, click here for a free trial
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