The NFL Week 5 schedule featuresgames that could end up being pivotal ones early in the season.
Which teams will win those games?
Check out The Arizona Republic's picks and predictions for each game on the NFL Week 5schedule.
Click on each game for picks and predictions for that game from other sites. All times MST.
NFL Week 5 odds:
- Colts vs. Broncos | Giants vs. Packers | Steelers vs. Bills
- Chargers vs. Browns | Texans vs. Jaguars | Bears vs. Vikings
- Lions vs. Patriots | Seahawks vs. Saints | Dolphins vs. Jets
- Falcons vs. Bucs | Titans vs. Commanders | 49ers vs. Panthers
- Eagles vs. Cardinals | Cowboys vs. Rams | Bengals vs. Ravens
- Raiders vs. Chiefs | Spreads, lines, over/unders | Super Bowl
Thursday Night Football schedule
Indianapolis Colts vs. Denver Broncos, 5:15 p.m., Amazon Prime
The Broncos are 2-0 on the season at home. We think that their defense will do enough against Matt Ryan to make it 3-0 after Week 5.
Prediction: Broncos 24, Colts 17
NFL Week 5 schedule:How to watch Week 5 NFL games
Sunday early football games
New York Giants vs. Green Bay Packers, 6:30 a.m., NFL Network
The New York Giants continue to surprise us. We'd be really surprised if they beat the Packers to move to 4-1 in London on Sunday.
Prediction: Packers 27, Giants 17
Pittsburgh Steelers vs. Buffalo Bills, 10 a.m., CBS
The Bills' defense has to be salivating anticipating going up against rookie quarterback Kenny Pickett.
Prediction: Bills 35, Steelers 14
Los Angeles Chargers vs. Cleveland Browns, 10 a.m., CBS
We think the Chargers go back on track against the Texans last week, but it was just the Texans.
Prediction: Chargers 24, Browns 21
Houston Texans vs. Jacksonville Jaguars, 10 a.m., CBS
Trevor Lawrence and the Jaguars will pick up their third win of the season in Week 5 when they face the winless Texans.
Prediction: Jaguars 35, Texans 20
Chicago Bears vs. Minnesota Vikings, 10 a.m., Fox
This game between NFC North rivals is big. We also think the Vikings' offensive numbers in this one will be big.
Prediction: Vikings 38, Bears 24
NFL Week 5 picks, predictions:
- Colts vs. Broncos | Giants vs. Packers | Steelers vs. Bills
- Chargers vs. Browns | Texans vs. Jaguars | Bears vs. Vikings
- Lions vs. Patriots | Seahawks vs. Saints | Dolphins vs. Jets
- Falcons vs. Bucs | Titans vs. Commanders | 49ers vs. Panthers
- Eagles vs. Cardinals | Cowboys vs. Rams | Bengals vs. Ravens
- Raiders vs. Chiefs | For subscribers: The Republic's NFL picks
Detroit Lions vs. New England Patriots, 10 a.m., Fox
The Lions' offense has been great this season, it's the defense that has huge question marks. But New England has questions at QB.
Prediction: Lions 34, Patriots 21
Seattle Seahawks vs. New Orleans Saints, 10 a.m., Fox
The Saints have had some tough luck and injuries this season. We predict that they will bounce back against the Seahawks at home.
Prediction: Saints 24, Seahawks 17
Miami Dolphins vs. New York Jets, 10 a.m., CBS
Zach Wilson returned from injury to lead the Jets to a Week 4 win. Can he lead them to another win in Week 5? Yes, he can.
Prediction: Jets 27, Dolphins 24
Atlanta Falcons vs. Tampa Bay Buccaneers, 10 a.m., Fox
The Falcons have won two straight game to move to 2-2. Their streak will come to an end on Sunday.
Prediction: Buccaneers 34, Falcons 24
Tennessee Titans vs. Washington Commanders, 10 a.m., CBS
The Commanders have dropped three straight after a win in Week 1. It will be four straight losses after Week 5.
Prediction: Titans 27, Commanders 21
NFL power rankings:Philadelphia Eagles, Dallas Cowboys, New York Giants shine
Sunday late football games
San Francisco 49ers vs. Carolina Panthers, 1:05 p.m., CBS
Baker Mayfield and the Panthers' struggles this season will continue in a loss to the 49ers.
Prediction: 49ers 30, Panthers 20
Philadelphia Eagles vs. Arizona Cardinals, 1:25 p.m., Fox
The Eagles have been the cream of the NFL crop so far this season, but the Cardinals did appear to find their footing in the second half against the Panthers. Philadelphia will win a thriller in Arizona.
Prediction: Eagles 38, Cardinals 35
Dallas Cowboys vs. Los Angeles Rams, 1:25 p.m., Fox
No Dak Prescott, no problem? Cooper Rush and the Cowboys are 3-1, but the Rams' defense will give the QB fits in Los Angeles.
Prediction: Rams 31, Cowboys 24
Super Bowl odds:NFL Week 5betting odds for every NFL team to win 2022-2023 Super Bowl
Sunday Night Football schedule
Cincinnati Bengals vs. Baltimore Ravens, 5:20 p.m., NBC
Interestingly, the Ravens are 0-2 at home and 2-0 on the road this season. This game is in Baltimore ...
Prediction: Bengals 27, Ravens 24
Monday Night Football schedule
Las Vegas Raiders vs. Kansas City Chiefs, 5:15 p.m., ESPN, ESPN2
After somehow losing to the Colts, the Chiefs looked more like the Chiefs in their Week 4 win over the Buccaneers. We think the Week 4 team will show up in Week 5 against the Raiders.
Prediction: Chiefs 40, Raiders 28
NFL Week 5 odds:Point spreads, moneylines, over/under for every Week 5 NFL game
Reach Jeremy Cluffat jeremy.cluff@arizonarepublic.com.Follow him on Twitter @Jeremy_Cluff.
